Dane, my prayers go with you to Houston. I feel certain you will
make the right decision about your treatment, you are in one of the
best places in the world for CML. Keep your spirits up, we are all
on your side. God's Blessings, Love & Hugs,
Marlene
>
> --- In [email protected], "Dane T." <[EMAIL PROTECTED]> wrote:
> > I received my first set of cytos since relapsing.
> > The news is not great....
> > Looks like I will be back in Houston sooner than expected.
> >
> > > Dear Mr. Tessler:
> > >
> > > I have attached the cytogenetics results below:
> > >
> > > Ph+ clone 48,XY,+8,+8,t(9;22)(q34;q11.2)[11]
> > > 2 metaphases photographed/karyotyped
> > >
> > > Diploid male karyotype 46,XY[9]
> > > 2 metaphases photographed/karyotyped
> > >
> > > Although the number of abnormal metaphases is less than has
been
> the case
> > > before, there are additional cytogenetic changes consistent
with
> clonal
> > > evolution in addition to the Philadalephia chromosome (i.e.
clonal
> > > evoluation consistent with accelerated phase). The options are
to
> continue
> > > with the combination as is (after all you only have been
treated
> for 3
> > > cycles), OR to try a different approach such with one of the
> newer
> > > tyrosine
> > > kinase inhibitors (e.g. AMN107). Personally, I prefer the
latter.
> I have
> > > already put out my feelers with the research nurse of the AMN
> protocol. If
> > > you wanted to consider this as well, we should get you back
> earlier, like
> > > next week. Also you would have to be off imatinib and any
> additional
> > > investigational agents. Let me know what you think.
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