Dane,

Although at the time you moved from Florida to Texas, it may have 
seemed bittersweet - it must have been destiny to place you so close 
to the best in this fight.  I just know you will persevere.

Kathy in Ct


--- In [email protected], "Dane T." <[EMAIL PROTECTED]> wrote:
> I received my first set of cytos since relapsing.  
> The news is not great....
> Looks like I will be back in Houston sooner than expected.
> 
> > Dear Mr. Tessler:
> >
> > I have attached the cytogenetics results below:
> >
> > Ph+ clone 48,XY,+8,+8,t(9;22)(q34;q11.2)[11]
> >                   2 metaphases photographed/karyotyped
> >
> > Diploid male karyotype 46,XY[9]
> >                   2 metaphases photographed/karyotyped
> >
> > Although the number of abnormal metaphases is less than has been 
the case
> > before, there are additional cytogenetic changes consistent with 
clonal
> > evolution in addition to the Philadalephia chromosome (i.e. clonal
> > evoluation consistent with accelerated phase). The options are to 
continue
> > with the combination as is (after all you only have been treated 
for 3
> > cycles), OR to try a different approach such with one of the 
newer 
> > tyrosine
> > kinase inhibitors (e.g. AMN107). Personally, I prefer the latter. 
I have
> > already put out my feelers with the research nurse of the AMN 
protocol. If
> > you wanted to consider this as well, we should get you back 
earlier, like
> > next week. Also you would have to be off imatinib and any 
additional
> > investigational agents. Let me know what you think.





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