New drug for Kaposi's Sarcoma

Reported by Susan Aldridge, PhD, medical journalist

Gleevec is an effective new treatment for Kaposi's sarcoma, the skin cancer that often affects people with HIV/AIDS
Up to 20 per cent of those with HIV/AIDS develop an otherwise rare skin cancer called Kaposi's sarcoma (KS). It is estimated that KS contributes to about 30 per cent of all AIDS-related deaths. The raised dark purple, red or brown lesions of KS are also very disfiguring and can cause a lot of emotional distress.

Researchers at Beth Israel Deaconess Medical Center now report that the new anti-cancer drug imatinib mesylate (Gleevec) is effective in treating KS. Five men with KS, all HIV positive and taking antiretroviral therapy, were given Gleevec twice daily for four weeks. The lesions began to clear up in as little as two weeks - with one man experiencing a 90 per cent regression, and two others seeing regressions of 73 per cent and 58 per cent. In the other cases, the disease was at least stabilized.

Gleevec is already licensed for treatment of chronic myelogenous leukemia and a rare form of stomach cancer. The work with KS is now to be extended by a further clinical trial.

Source
American Society of Clinical Oncology Meeting 4th June 2003



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