Hi Cheryl Anne and Chris, Creatinine is a muscle breakdown product which is exclusively cleared from the body by the kidneys. Unlike BUN (blood urea nitrogen), which waxes and wanes with kidney perfusion (how well hydrated you are, that is), creatinine builds up more slowly and is therefore a moderately good indicator of kidney function, not just of hydration. There are exceptions though, the main one being, as Cheryl-Anne says, when you exercise especially hard (or whack a muscle, for that matter). Then, a lot of muscle protein can end up in your serum and since it's cleared at a steady rate, it can show up elevated on the metabolic panel.
I have wondered whether IM affects kidney function though. Curiously, my creatinine was high-normal and sometimes even a little elevated the first couple of years I was on the drug, though it's been in the mid-normal range ever since. My BUN is often high, but I think that's because I don't drink enough water when I exercise. Cheers, Richard R > Date: Fri, 21 Jan 2005 15:10:51 -0000 > From: "cher111376" <[EMAIL PROTECTED]> > Subject: Re: Elevated Creatinine > > > Hi Chris, > > As you know, I am not a doctor and maybe Richard R will chime in on > this one. I think that higher creatinine levels has something to do > with dehydration. Have you been keeping up on your fluid intake? > Another reason for higher creatinine levesl would be weight training > and increase in sports and phsycial activity. > > I know of someone recently on gleevec who had higher creatinine > levels and increased their fluid intake. On the next test the levels > were back to normal. > > Hope this helps and please keep us posted, > > Cheers, > Cheryl-Anne ------------------------ Yahoo! Groups Sponsor --------------------~--> Give the gift of life to a sick child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/3iazvD/6WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
