Dear Rob, this is fabulous news, so exciting.  Come on FDA, give it 
approval for clinical trials quickly. People with T315I need this 
now.
Best wishes
Annette


--- In [email protected], "Rob" <[EMAIL PROTECTED]> wrote:
> Temple University researchers have developed a new drug that could 
potentially treat all forms of Gleevec-resistant chronic myelogenous 
leukemia (CML). Their work is published in this week's early edition 
of Proceedings of the National Academy of Sciences...Recently, two 
experimental drugs were found to be effective in circumventing some 
but not all forms of Gleevec resistance. Both, for instance, failed 
to block the activity of a mutant BCR-ABL, called T315I, which is 
one of the more predominant mutations seen in Gleevec-resistant 
patients. Reddy and his research team sought instead to develop a 
drug that would circumvent all of the mutations and therefore all 
forms of resistance....when patients become resistant to Gleevec, 
our drug kills 100 percent of the cancer cells," said Reddy.   
> 
> http://cmlsupport.blogspot.com/2005/01/new-leukemia-drug-shows-
promise-in.html





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