Hello David,
Thanks for your post. You are refering to the trial that is being headed up in Scotland by Dr. Tessa Holyoake. She is a very nice Dr and I was so happy to meet with her at ASH in December. The work she is doing is really quite exciting and quite a few of us on this site will be interested to hear reports of how it is going. I hope to go to Scotland early this summer. My mother was a Fraser and it is about time to go visit Aberdeen. You sound like you are doing very well and I hope you do get in this trial. If I was over in Scotland and was eligible I might consider it myself! All the best to you and thanks for joining this group and sharing with us. Cheers, Cheryl-Anne (Montreal, Canada) Dxed Nov 2000 IFN (low dose) PCRU June 2002 Started Gleevec Jan 2003 PCRU (again)and holding(?) June 2003 --- In [email protected], "david_8522000" <[EMAIL PROTECTED]> wrote: > > Hi > > I am 25 and live in Scotland, I was diagnosed with CML in March 04, > I was at diagnosis I had a 54.5% Ph+ after 8 months on Glivec 400mg > I now am 0.016% Ph+ so responding well. > > Initially I did not really want to become involved in the CML > Community, however the last few months I have been tracking > discussions and found I want to know more about this condition. At > diagnosis I was given a booklet five or six years out of date which > painted a very bleak picture, this has changed so much in a few > short years, if this rate of development continues I for one am very > hopeful that a complete cure is just a few years away, I now find > myself worrying about long term side affects of relatively untested > drugs instead of the thought of not reaching my 30th birthday. > > I may have the opportunity to participate in a Phase 1 Clinical > Trial which will involve 45 people. The trial is for people > responding well to Glivec. There will be three parts to this trial > and I wouldn't be able to choose which arm I would be on. > > � 15 people will take Glivec as normal > � 15 people will take a pulsed dose of Glivec 3 weeks on one > week off > � 15 people will take a pulsed dose of Glivec 3 weeks on one > week off, injecting growth factor in the week off of Glivec. > > Pulsing Glivec > Whilst off Glivec sleeping Leukaemia cells have time to wake up, > divide once active Glivec should be able to shut them down. > > Growth Factor > The growth factor will be applied in the week off Glivec this should > force any sleeping cells to wake up, divide, again once the cell has > become active Glivec should be able to shut it down. > > The theory > Allowing or forcing the leukaemia to grow then in turn makes it an > easy target for Glivec to shut down, this is hoped to turn low PCR > results to negative PCR results. > > I will not be eligible for this trial until I have been stable for > six months that will be at 11 months on Glivec. So I may be too late > to participate in this trial. > > This is a Phase 1 trial so just about completely untested though I > feel very positive about it, I was wondering if anyone had > experience of using growth factor (I think it's called GCFS) in > combination with Glivec possibly for Stem Cell Collection, or > pulsing of doses of Glivec? > > Thanks David ------------------------ Yahoo! Groups Sponsor --------------------~--> Give the gift of life to a sick child. Support St. Jude Children's Research Hospital's 'Thanks & Giving.' http://us.click.yahoo.com/3iazvD/6WnJAA/xGEGAA/8zSolB/TM --------------------------------------------------------------------~-> New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all types of business and commercial real estate. Apply anytime at http://realestatezoo.com CML (Chronic Myelogenous Leukemia Support List) --------------------------------- Part Of CMLHope.Com An International Community Of CML Patients For more information: http://cmlhope.com Post Message: [email protected] Subscribe: [EMAIL PROTECTED] Unsubscribe: [EMAIL PROTECTED] Change To No Mail/Web: [EMAIL PROTECTED] Change To Digest: [EMAIL PROTECTED] Change To Email: [EMAIL PROTECTED] List Help: [EMAIL PROTECTED] CML Group Web Site http://groups.yahoo.com/group/CML Yahoo! Groups Links <*> To visit your group on the web, go to: http://groups.yahoo.com/group/CML/ <*> To unsubscribe from this group, send an email to: [EMAIL PROTECTED] <*> Your use of Yahoo! Groups is subject to: http://docs.yahoo.com/info/terms/
