Hi Jim, thanks for this information. My trisomy 8 is in my ph neg cells and apparently it's not as significant as trisomy 8 in ph positive cells. I'll be seeing my doctor next Wednesday & I've got loads of questions to ask him, so I'll let you know what he says. Quite a few people who've had this abnormality have later seen it disappear - so it's something to keep a close eye on, thanks again, Barbara--- In [email protected], "James Beck" <[EMAIL PROTECTED]> wrote: > Hi To All, > Here is some information that I found while searching on Google. I searched the word Trisomy 8...and this was the result. Hope this helps. > > Regards, > Jim Beck - PA > dx 8/2001 > gleevec 600mg > > +8 or trisomy 8 > Clinics and Pathology > > > Disease chronic myelogenous leukaemia (CML) > Epidemiology +8 is one of the major anomalies additional to the t(9;22), with i(17q), + der(22), before +19; found as a unique additional anomaly in 10%, with other in 25% of CML cases with clonal evolution; these additional anomalies may be present at the diagnosis of CML (in 10%, possibly with unfavourable significance), or may appear during course of the disease, they do not indicate the imminence of a blast crisis, although they also frequently emerge at the time of acute transformation; +8 is more often found in the myeloid than in the lymphoid blast crisis. > Prognosis +8 has apparently no prognostic significance in CML > > > Check the site shown below....seems to have a lot of other information... > ( looks like a site originating from France) > > Web Site - http://www.infobiogen.fr/services/chromcancer/Anomalies/tri8ID1017.ht ml
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