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Chronic myelogenous leukemia (CML) is a malignant disorder of the
hematopoietic stem cell characterized by the BCR-ABL oncogene. We examined gene
_expression_ profiles of highly enriched CD34+ hematopoietic stem and progenitor
cells from patients with CML in chronic phase using cDNA arrays covering 1.185
genes. Comparing CML CD34+ cells with normal CD34+ cells, we found 158 genes
which were significantly differentially expressed. Gene _expression_ patterns
reflected BCR-ABL-induced functional alterations such as increased cell-cycle
and proteasome activity. Detoxification enzymes and DNA repair proteins were
downregulated in CML CD34+ cells, which might contribute to genetic instability.
Decreased _expression_ of junction plakoglobulin and CXC chemokine receptor 4
(CXCR-4) might facilitate the release of immature precursors from bone marrow in
CML.
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