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It has been shown that p210(BCR-ABL) significantly impairs CXCR4 signaling.
We report here that the migratory response to SDF-1 was profoundly altered in
blast crisis, whereas chronic-phase CD34(+) cells migrated normally to this
chemokine. This migratory defect was associated with a low CXCR4 membrane
_expression_. In vitro STI-571 treatment of CD34(+) cells from patients in blast
crisis markedly increased the CXCR4 transcript and CXCR4 membrane _expression_.
Because p210(BCR-ABL) frequently increases with disease progression, we
determined the effects of high and low p210(BCR-ABL) _expression_ on CXCR4 protein
in the granulocyte macrophage colony-stimulating factor-dependent human cell
line MO7e. p210(BCR-ABL) _expression_ distinctly alters CXCR4 protein through two
different mechanisms depending on its _expression_ level.
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