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Previous studies have shown that BCR/ABL oncogene, the molecular
counterpart of the Ph1 chromosome, could represent a privileged target to
natural killer (NK) cells. In the present study, we showed that activated
peripheral NK cells killed high-level BCR/ABL transfectant UT-7/9 derived from
the pluripotent hematopoietic cell line UT-7 with a high efficiency. To further
define the mechanisms controlling BCR/ABL target susceptibility to NK-mediated
lysis, we studied the effect of IFNgamma, a key cytokine secreted by activated
NK cells, on the lysis of these targets.
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