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Imatinib mesylate is a novel anti-tumor agent useful in the clinical
management of chronic myelogenous leukemia and gastrointestinal stromal tumors
with minimal toxicity relative to other forms of cancer therapy. Its clinical
activity and minimal toxicity are related to specific inhibition of cellular
targets including BCR-ABL, platelet-derived growth factor receptor and c-kit
kinases, resulting in the collapse of downstream signaling cascades important
for transformation. In some patients, unexpected toxicities arise that are not
associated with inhibition of any known cellular imatinib target.
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