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Imatinib mesylate is a novel tyrosine kinase inhibitor used for the
treatment of Philadelphia chromosome positive (Ph+) leukemia and other
malignancies. In previous studies, we found significant telomere shortening in
Ph+ cells from patients with chronic myeloid leukemia (CML). Interestingly,
imatinib treatment was found to lead to a normalization of previously shortened
telomere length in CML patients. Based on recent reports demonstrating that
c-ABL phosphorylates hTERT and thereby inhibits hTERT activity, a direct effect
of imatinib on hTERT activity leading to telomere elongation in BCR-ABL-positive
cells has been proposed by others. Such an effect could be of potential
importance for telomere maintenance in Ph+ cells by facilitating clonal
selection and progression of the disease to blast crisis.
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