Hi. Those are good questions you raised regarding the dosing of Gleevec. My daughter (age 33 - diagnosed May 13, 2005) is on 600 mg. of Gleevec. This dose was decided because she went to two great places for opinions...UCLA and OSHU in Portland, Oregon. Both doctors said the current thinking is 600 mg. because it will put her in a deeper remission, faster. What you are hearing about building a resistance to the Gleevec makes sense except that I had heard that was more probable at doses less than 400 mg. Yes, you hate the pills, but they are going to keep you alive until a CURE comes along, so take them, eat plenty with them, and drink lots of fluids. If you are nauseated, ask your doctor for something to take with it at the same time. (My daughter takes Zofran, which has been a miracle drug for her.) Our local oncologist wanted her to start on 400 mg and at the first sign of a problem on 600 mg, he wanted to drop her back to the 400 mg. but that is not the thinking if you listen to the teleconferences. He needs to deal with the symptoms (low WBC, low platelets.). As the doctor from MD Anderson said: you can't fight the caner if you don't take the drug. That is great that your sister is getting HLA typed. I am hoping for a match for you. We were disappointed that my children didn't match my daughter but there are two hopefuls in the 5.5 million registrants in the bone marrow registry, but my daughter is not opting for a transplant in the near future. She is hopeful with the Gleevec and whatever will follow. My suggestion for anyone diagnosed with this disease is to educate yourself with all the internet information. The Leukemia and Lymphoma Society sites are outstanding with lots of educational programs that explain all the testing in simple terms. Best wishes, Sue
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