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Aims This study was designed to investigate the biochemical and
physiological covariates or comedications that affect the pharmacokinetics of
imatinib mesylate in patients with chronic-phase chronic myeloid leukaemia (CP
CML). Methods Pharmacokinetic data were analyzed in 371 patients receiving 400
mg imatinib once daily during a phase III trial of imatinib vs interferon-alfa
plus cytarabine for the treatment of newly diagnosed CP CML.
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