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Idiopathic hypereosinophilic syndrome is characterised by chronic
hypereosinophilia leading to tissue damage, and after exclusion of reactive
eosinophilia. Until recently no specific or efficient therapeutic was available.
In 2003, a recurrent interstitial deletion 4q12 leading to the fusion of the
FIP1L1 and PDGFRA genes was detected in hypereosinophilic syndromes.
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