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We previously reported that the c-myb and Vav proto-oncogenes are amenable
to silencing with antisense oligodeoxynucleotides and that inhibition of either
impairs leukemic cell growth. Because the _expression_ of these genes is not known
to be linked, we sought to determine the therapeutic value of silencing both
genes simultaneously in K562 and primary patient (n = 9) chronic myelogenous
leukemia cells.
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