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The recent discovery of an eosinophilia-specific, imatinib-sensitive,
karyotypically occult but fluorescence in situ hybridization-apparent molecular
lesion in a subset of patients with blood eosinophilia has transformed the
diagnostic as well as treatment approach to eosinophilic disorders. Primary
(i.e. nonreactive) eosinophilia is considered either 'clonal' or 'idiopathic'
based on the presence or absence, respectively, of either a molecular or bone
marrow histological evidence for a myeloid neoplasm.
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