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BAY 43-9006, a multikinase inhibitor that targets Raf, prevents tumor cell
proliferation in vitro and inhibits diverse human tumor xenografts in vivo. The
mechanism of action of BAY 43-9006 remains incompletely defined. In the present
study, the effects of BAY 43-9006 on the antiapoptotic Bcl-2 family member Mcl-1
were examined
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