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A series of adenosine derivatives substituted at the 1'-, 2'-, or
3'-position of the ribose ring with a methyl group was synthesized and evaluated
for antitumor activity. From this study 3'-C-methyladenosine (3'-Me-Ado) emerged
as the most active compound, showing activity against human myelogenous leukemia
K562, multidrug resistant human leukemia K562IU, human promyelocytic leukemia
HL-60, human colon carcinoma HT-29, and human breast carcinoma MCF-7 cell lines
with IC(50) values ranging from 11 to 38 muM.
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