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OBJECTIVE: To study the effect of nonmyeloablative allogeneic peripheral
blood stem cell (NST) transplantation combined with imatinib in the treatment of
chronic myeloid leukemia (CML). METHODS: Ten CML patients, 5 males and 5
females, aged 21-41, 3 in chronic phase (CP), 4 in accelerated phase (AP) and 3
in blast crisis phase (BP), were treated with imatinib (400 - 1500 mg/d) before
(n = 10) and/or after (n = 6) NST transplantation. The donors were HLA-identical
(n = 4), 5/6 antigen-matched (n = 2), 4/6 antigen-matched (n = 2), 3/6
antigen-matched (n = 1) siblings or haplo-identical mothers (n = 2).
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