Doctors and patients around the world hailed the approval of Gleevec in 2001, which revolutionized the treatment of chronic myeloid leukemia and marked the beginning of what scientists hope will be a new era in cancer therapy.
Scientists engineered Gleevec to silence growth signals from a rogue protein that causes the blood cancer. Patients who were bedridden have returned to normal — often staying in remission for years, says Brian Druker, a professor at Oregon Health & Science University who developed Gleevec.
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