[CML] American Society of Hematology :: Discoveries Reveal Gene Mutation That Causes Blood Disorders

[Rob]

Several members of the American Society of Hematology (ASH) have
discovered a single point mutation in the JAK2 gene that is expressed
in a high percentage of patients with one of three myeloproliferative
diseases. The discovery of this mutation may lead to the development of
a targeted therapy to combat these disorders.Myeloproliferative
diseases (MPDs) are a closely related group of blood disorders
characterized by excessive production or dysfunction of blood cells.
The three main MPDs are polycythemia vera, essential thrombocythemia,
and idiopathic myelofibrosis. The actual incidence of MPDs is difficult
to measure, but the most complete statistics to date estimate that they
affect 4.7 people out of every 100,000. There is currently no known
cure for MPDs.http://cmlsupport.blogspot.com/2005/12/american-society-of-hematology.html






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