It is not unknown in the literature, but very rare.
| This case, added to two previously reported cases of the concurrence of CML and T-cell lymphoma, suggests a relationship between the two diseases, ... |
Sequential development of peripheral T-cell lymphoma in the course of chronic myelogenous leukemia.
Blonk MC, van der Valk P , Beverstock GC , Ossenkoppele GJ .
Department of Haematology, Free University Hospital, Amsterdam, The Netherlands.
A patient is described with chronic myelogenous leukemia (CML) and an unusual karyotype 46XY,t(Y;12) (q11;p12), whose clinical course was complicated by T-cell lymphoma 5 years later. At that time bone marrow cells showed an additional karyotypic abnormality 46XY,t(Y;12) (q11;p12) del(7) (pter-p21), which remained unchanged until blastic transformation of the CML 8 months later. The bone marrow biopsy specimen, which revealed the blastic transformation of the CML, also showed evidence for localization of T-cell lymphoma. This case, added to two previously reported cases of the concurrence of CML and T-cell lymphoma, suggests a relationship between the two diseases, which is discussed.
Publication Types:
Blonk MC, van der Valk P , Beverstock GC , Ossenkoppele GJ .
Department of Haematology, Free University Hospital, Amsterdam, The Netherlands.
A patient is described with chronic myelogenous leukemia (CML) and an unusual karyotype 46XY,t(Y;12) (q11;p12), whose clinical course was complicated by T-cell lymphoma 5 years later. At that time bone marrow cells showed an additional karyotypic abnormality 46XY,t(Y;12) (q11;p12) del(7) (pter-p21), which remained unchanged until blastic transformation of the CML 8 months later. The bone marrow biopsy specimen, which revealed the blastic transformation of the CML, also showed evidence for localization of T-cell lymphoma. This case, added to two previously reported cases of the concurrence of CML and T-cell lymphoma, suggests a relationship between the two diseases, which is discussed.
Publication Types:
PMID: 2400970 [PubMed - indexed for MEDLINE]
Occurrence of high-grade T-cell lymphoma in a patient with Philadelphia chromosome-negative chronic myelogenous leukemia with breakpoint cluster region rearrangement: case report and review of the literature.
Djulbegovic B, Hadley T, Yen F .
James Graham Brown Cancer Center, Department of Medicine, University of Louisville, Kentucky 40292.
In this report, we describe a patient with Philadelphia chromosome-negative chronic myelogenous leukemia (CML) with breakpoint cluster region gene rearrangement who developed T-cell lymphoblastic lymphoma. The occurrence of T-cell lymphoblastic lymphoma coincided with the appearance in the bone marrow of the cytogenetic abnormality, trisomy 22q11.2----22qter. This is the first report of high-grade T-cell lymphoma in a patient with documented CML.
Publication Types:
Djulbegovic B, Hadley T, Yen F .
James Graham Brown Cancer Center, Department of Medicine, University of Louisville, Kentucky 40292.
In this report, we describe a patient with Philadelphia chromosome-negative chronic myelogenous leukemia (CML) with breakpoint cluster region gene rearrangement who developed T-cell lymphoblastic lymphoma. The occurrence of T-cell lymphoblastic lymphoma coincided with the appearance in the bone marrow of the cytogenetic abnormality, trisomy 22q11.2----22qter. This is the first report of high-grade T-cell lymphoma in a patient with documented CML.
Publication Types:
PMID: 1984685 [PubMed - indexed for MEDLINE]
On 4/16/06, [EMAIL PROTECTED] <[EMAIL PROTECTED]> wrote:
Dearest Melody
Hello Melody and welcome to our group of fellow friends and warriors of
CML.
So sorry to hear of your misfortune. I hope you will soon find the
answer to this bizarre occurrence. I don't know if a doctor could give
you the answer you are looking for, but Dr. Druker would be the best to
correspond with since he designed Gleevec and is so knowlegeable on
CML. In my fogged up brain, I recall being told by my doctor that
leukemia can make you more susceptible to other cancers. I don't think
going off Gleevec for a short period of time would do this. There are
several in the group who have taken breaks from taking it for one
reason or another. Please know that you will be in our prayers and try
not to jump to conclusions until you learn more. Please feel free to
come forward with any questions that might arise. We are all here to
help each other if at all possible.
Please share with the group your findings so that others can learn from
your experience. I wish you the very best and my prayers are with you.
Love, Peace, Hope & Prayers, Pat
--
Zavie Miller (age 67)
67 Shoreham Avenue
Ottawa, Canada, dxd AUG/99
INF OCT/99 to FEB/00, CHF
No meds FEB/00 to JAN/01
Gleevec since MAR/27/01 (400 mg)
CCR SEP/01. #102 in Zero Club
PCRU 5/02 at RVH
2.8 log reduction Sep/05
3.0 log reduction Jan/06
e-mail: [EMAIL PROTECTED]
Tel: 613-726-1117
Fax: 309-296-0807
Cell: 613-202-0204
Yahoo ID: zaviem
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