Hi Allyson,

If I remember correctly, you are on 800mg of Gleevec and one weekly
injection of peg interferon.  According to the latest data from the
dasatinib trials and the opinion of some CML experts, the side effects
of the 800mg of IM alone would cause the problems you are metnioning as
far as digestive problems, and memory issues.  These might not be
specifically linked to IFN.  In fact I know one patient who is on 800
mg of IM as part of a trial and she has significant GI problems and
memory issues and she never took IFN.  It just may be in your case, the
doctors are prepared to drop the IFN to stay with IM because it has
better longer term results?  I think this is the fundamental problem
with the trial at MD Anderson.  Having people take 800mg of IM and IFN
can get quite debilitating.  Especially in your case, if I remember
correctly you got into this trial just after being dxed.  The point
with IFN is that it is supposed to stimulate an immune response,
overdosing either IM or IFN seems to greatly diminish our QOL without
the potential to cure us.  You are very brave for doing this though.
Hopefully, we have all learned something from this.

Keep us posted,

Cheers and warm wishes,
Cheryl-Anne


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