Dear Mary, While WBC may remain normal on Hydrea for a while, it does not do much for the cancer in the marrow. His Ph percentage may remain high and his disease advance in time. Historically, majority of patients on Hydrea have advanced in their disease and that is why Hydrea is not a drug of choice to treat CML, it does not reduce the cancer marker in the marrow. What you do not want is for his disease to advance into accelerated phase or blast crisis on Hydrea and then even the new drugs may not give durable remissions. They work best in chronic phase.
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