Anjana,
When you typed this letter was the first time I kinda understood about log reductions and the PCR values. Sooo I printed it out and took it with me to my Onc. appt this morning. I asked him what my PCR value was when I was first diagnosed.....it was 100% is that as bad as it sounds? But the good thing was four months ago he did a gene rearrangement and my PCR was 0. What would the log reduction be on that? He was going to do another one today but I have just about had pneumonia in the last month and have been on antibiotics and steriods so he said he was going to wait four more weeks to do it.
Hugs,
Katy
--
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-------------- Original message --------------
From: "anjana" <[EMAIL PROTECTED]>
>
> Hi Lori,
>
> A 1-log reduction is 10-fold reduction, 2-log is 100-fold and 3-log
> is 1000-fold reduction from diagnosis PCR value. Doctors like patients
> to reach a 1000-fold or 3-log reduction and that is one of the goals of
> Gleevec therapy. You are between a 1 and a 2-log reduction so you are
> on your way to higher log reductions.
>
> Suppose a patient had 43% PCR value at diagnosis, a 1-log reduction
> would be 4.3%, a 2-log reduction would be 0.43% and a 3-log reduction
> would be 0.043%.
>
> That was an illustration. Exact PCR numbers will differ from lab to
> lab and some labs nowadays report only logs. At 6 months of Gleevec,
> doctors like to see a 2-log reduction and st udies have shown that if
> there is a 3-log reduction at 12 months of Gleevec, there is 100%
> protection from progressing to advanced disease phases for 5 years.
>
> It is enough for you to know the log reduction. If this is your
> first PCR, this can be a baseline. Your goal is 3-log so in subsequent
> PCRs, hopefully, the trend will be towards the 3-log goal, like 2-log,
> then 2.5-log, 3-log, etc.
>
> Hope this was not too confusing.
>
> Best Wishes,
> Anjana
> caregiver to Roy
>
>
>
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