Thanks Anjana, I knew you would be as on top of this issue as anyone.
In one of the study abstracts you cited it says, "Preliminary data
suggest that D is more effective and better tolerated than high dose
IM."  I think that was written quite a while ago during an early phase
of testing Sprycel.  Everything I've seen published recently supports
that early finding.  In the trials, the only patients tested on Sprycel
were those that couldn't take Gllevec or Gleevec didn't work.  Frankly,
I think there must have been some political or industrila pressures
brought to bear.  I cannot see why the drug couldn't have been tested
on CML patients who did get a decent response from Gleevec.  Seems to
me that one wouldn't have to be on such a test for very long to find
out.

Mike


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