The IRIS Study has shown that Gleevec is far superior to the previous
drugs.  Even if people initially responded to Interferon, Ara-C, and
Hydroxyurea, these responses were not as deep and durable as with
Gleevec, so long term survival rates were poor when compared to the
95% overall survival rate for Gleevec.  Besides the lack of long term
benefit, many people could not tolerate the side effects from those
drugs.  Hydroxyurea is still used for some at initial diagnosis when
WBC counts are extremely high to gain a rapid reduction in leukemia
cells, but then Gleevec is used soon after that.  There are a few who
beat the odds on earlier drug therapy, but they were rare cases, and
their quality of life was often poor.

http://www.sciencedaily.com/releases/2007/12/071210094338.htm
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