Dear Carl, Doctors look at lab studies and clinical trial results to choose the best drug for a particular mutation. The lab data for the IC50 of Nilotinib is 70nM and Dasatinib is 25nM. IC50 is the concentration of the drug required to kill 50% of the cells in the sample. So since Dasatinib needs less of it to kill the mutation, it has more potency than Nilotinib on the G250E mutation in the lab.
I don't know if you got my private mail but I gave the European Hematology Association 2007 abstract from Dr. Hughes where clinical trial results show the G250E mutation being detected during Nilotinib therapy. There is a chart there you need to look at. I tried to cut and paste the chart here to no avail. Please email me if you did not receive my mail, Carl. 5 patients developed the G250E mutation during Nilotinib therapy and 2 of them progressed in disease so for 2 of them, the mutation was not overcome. Please feel free to email me, privately, anytime. I am here for you and you will get through this, don't worry. Warm Regards, Anjana Mutations that developed during nilotinib therapy On Feb 20, 8:19 am, "[EMAIL PROTECTED]" <[EMAIL PROTECTED]> wrote: > Dear Group: > I have had CML for five years and have recently developed the G250E > mutation which, I understand, is sensitive to both dasatinib and nilotinib. > I am now on 800 mg. of imatinib but PCR has gradually risen over the past > months from neglible to .5% PCR from the bone marrow and .3% PCR from > peripheral blood. FISH is 0/500 down from 2/500 about a month ago. > Cytogenetics are pending. > My doc at MSKCC, who is considering switching me to dasatinib, says the > response data for patients for both these drugs is rather sparse. > Does anyone have info. or data on the G250E mutation and which drug is > most effective. It looks as if Gleevec and I will be getting a divorce. > Many thanks, > Carl Davies > Allentown, PA, USA > > _____________________________________________________________ > Victim of medical malpractice? Click here to find an expert lawyer to help > pursue your > case.http://thirdpartyoffers.netzero.net/TGL2211/fc/Ioyw6ijneFgZraebtYUzAg... --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
