You may consider emailing Neil Shah at UCSF who
has been compiling data on the sensitivity of
different mutants to the 3 drugs.
ho
== 1 of 1 ==
Date: Tues, Feb 19 2008 4:19 pm
From: "[EMAIL PROTECTED]"
Dear Group:
I have had CML for five years and have recently
developed the G250E
mutation which, I understand, is sensitive to both
dasatinib and
nilotinib. I am now on 800 mg. of imatinib but PCR
has gradually risen over
the past months from neglible to .5% PCR from the
bone marrow and .3%
PCR from peripheral blood. FISH is 0/500 down from
2/500 about a month
ago. Cytogenetics are pending.
My doc at MSKCC, who is considering switching me
to dasatinib, says
the response data for patients for both these drugs
is rather sparse.
Does anyone have info. or data on the G250E
mutation and which drug
is most effective. It looks as if Gleevec and I will
be getting a
divorce.
Many thanks,
Carl Davies
Allentown, PA, USA
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