Besides the low dosage issue, you might also want to ask the Onc to do a "Mutation Analysis" to see if Jim has become resistant to Gleevec. If so, he would need to switch drugs. Here is a discussion of this test: http://www.aruplab.com/TestDirectory/resources/TechnicalBulletins/BCR-ABL1%20Kinase%20Domain%20Mutation%20Jan%202007.pdf
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