Thank you very much for this information! Now, another question. My PCR in 2/08 was .0007 (done at ARUP labs). PCR at Quest in 8/08 was . 006. Now, PCR at Quest in 10/08 is up to .015. Based on my understanding of the baseline for Quest, I was nearly 3 log in August, but am now trending up, closer to 2 log. I'm not sure the ARUP result can even be compared. My Dr suggests upping the gleevec or trying a new drug. I would like to do one more Quest PCR in about 6 weeks before I would make a change. I'm also thinking of a BMB to verify that my CCR is still intact. Any thoughts/advice would be very much appreciated. You good people have a MUCH better understanding of this than my Dr. Thank you so much!
On Oct 28, 2:59 pm, lbailes <[EMAIL PROTECTED]> wrote: > From my last lab test from Quest: > > "Our data shows that, in our laboratory, the median of BCR-ABL:ABL > ratio in previously untreated CML patients is 4.1325 in peripheral > blood samples (N=120) and 5.09 in bone marrow samples (N=109). Based > on the IRIS study (New England Journal of Medicine, 2003, > 349:1423-1432), it is not necessary to know the BCR-ABL:ABL ratio of a > patient at baseline to calculate the subsequent change and this > claculation should be based on the above-mentioned median. Based on > this study, a 3 log or higher reduction by 12 months of therapy is > associated with neligible risk of disease progression during the > subsequent 12 months when patients are treated with imatinib. > > The following formula is used for calculating log reduction: > > LOG10(4.1325)-LOG10(BCR-ABL:ABL ratio) Unit/Log reduct." > > On Oct 28, 1:47 pm, Kathy Hyland <[EMAIL PROTECTED]> wrote: > > > > > Does anyone know the PCR baseline for Quest labs? Thanks!- Hide quoted > > text - > > - Show quoted text - --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
