It seems clear that your PCRs are increasing steadily, and a 1 log increase will usually suggest that the issue should be investigated. I would ask your Onc to perform a Kinase Domain Mutation Analysis (also known as a Gleevec Resistance Test), and ARUP Labs does this test. Here is a link: http://www.aruplab.com/TestDirectory/resources_testDirectory/TechnicalBulletins/BCR-ABL1%20Kinase%20Domain%20Mutation%20Jan%202007.pdf
The test will show if you have a Gleevec resistance mutation. If so, you will need to switch drugs. If not, you could increase Gleevec dosage, or you could still switch drugs. --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
