Daniel, I think that you should stay on gleevec. But you should try a good diet. My son has had fatigue too and he is doing better since he started to take garlic capsules and green tea. You should read the book anti-cancer ( David Servan). keep going, Ricardo.
On Thu, Oct 30, 2008 at 7:47 PM, daniel <[EMAIL PROTECTED]> wrote: > > hi all, > i have a dilemma with my treatment that i have been mulling over > awhile and would like your thoughts. i've now been on gleevec 400mg/ > daily since being diagnosed in sept 2007 and am in complete > cytogenetic remission as of my 1 year followup last month (this was > confirmed in both peripheral and marrow fish and marrow karyotype). my > pcr results are decent/good, almost at 3log decrease and still > declining at a fast rate. so, it would be fair to say that the drug is > moderately-to-very efficacious in my case. the problem is that i have > experienced debilitating fatigue since very early in gleevec > treatment. it doesn't seem to due to low hemoglobin (~13.5 +/- .3) and > there are no detectable cellular/biochemical abnormalities in my blood > work-up. but i feel terrible--i require 9+ hours of sleep nightly and > fade dramatically after just a couple of hours of being active. i'm 31 > years old and this was never an issue before i started taking gleevec. > i also look notably more wan, especially after a bit of activity. i am > currently doing post-doctoral work and can work mainly from home, but > would eventually like to work a real job, and it is difficult for me > to see how this will be possible in my current circumstance. overall, > i would rate my quality of life pretty poor. > > as i see it i have a few options: > 1) suck it up, stay on gleevec 400 mg/daily, and try to work around my > side-effects as best i can > 2) try a 2nd generation TK inhibitor > 3) wait until i hit 3log reduction and reduce gleevec dosage to 300mg/ > daily > > any thoughts? another complicating issue is getting insurance ok for a > 2nd generation inhibitor if i choose to go that route. my doctor has > subtly implied that he doesn't feel that my side-effects warrant a > change of drug. i realize that the insurance decision will be based > largely on doctor assessment, so i didn't push as i don't want such a > discussion recorded in his notes. am thinking about switching to more > sympathetic doctor. > > any thoughts would be appreciated. > best, > daniel > > > > --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
