Hi Dawn, Log reduction is just a mathematical term. It means 10 times greater or ten times less.
So, we use the term log reduction most of the time when we are talking about CML. If you have a 1 log reduction with your CML it means that there are 10 times less CML cells in your system since the last time you measured it. If it is a 2 log reduction, it means that there are 100 times less CML cells. And a 3 log reduction means 1,000 times less CML cells. In order for this to be meaningful you need to know how many CML cells you started with at diagnosis time. Since very few of us had a PCR test done at diagnosis time, each lab makes a guess at what the CML level was at diagnosis time for CML patients at that lab. You don't have to know what that number is because all the labs report your results in log reduction. If you look at my results you will see that I am at a 3.8 log reduction. This means that the CML level in my system is 1,800 times less than it was at diagnosis time. A very good place to be. Many times you will read that someone is at PCRU. This means that the lab performing the PCR test could not find any CML cells in your system. Well, it turns out that some labs do very sensitive PCRs and others do less sensitive PCRs. So, if you took two samples of your blood to two different labs one result could come back as a 3.8 log reduction and the other could come back as PCRU or undetectable. All this means is that the second lab had a less sensitive test than the first one. In order to be able to see how you are doing, you need to be tested at the same lab under the same conditions in order to compare results. I realize that this was a long winded answer and I hope it helped to unravel the mystery of log reduction. A couple of numbers to be aware of. If your resut is a 2 log reduction it means that you are in CCR (Complete Cytogenic Response). If your result is a 3 log reduction it means that you are in MMR (Major Molecular Response). Once you reach MMR there is virtually no chance that you will relapse with your CML. I assign Zero Club numbers when a patient achieves CCR. Zavie Zavie Miller (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 3.8 log reduction Aug/09 e-mail: [email protected] Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 Yahoo ID: zaviem On Wed, Oct 21, 2009 at 10:39 AM, DAWN RODEGHIER <[email protected]>wrote: > Zavie, I don't know what LOG REDUCTION is or how it effects our Leukemia! > Could you explain it! I'm probably not the only one that needs this > knowledge. Jim Rodeghier > > --- On *Tue, 10/20/09, Zavie Miller <[email protected]>* wrote: > > > From: Zavie Miller <[email protected]> > Subject: [CMLHope] Novartis drug TasignaR meets primary endpoint in pivotal > trial against GlivecR as first-line treatment in chronic myeloid leukemia > patients > To: [email protected], [email protected] > Date: Tuesday, October 20, 2009, 11:40 PM > > > > > * > http://www.pipelinereview.com/index.php/2009102030206/Small-Molecules/Novartis-drug-Tasigna-meets-primary-endpoint-in-pivotal-trial-against-Glivec-as-first-line-treatment-in-chronic-myeloid-leukemia-patients.html > *** > > > > > > > > Zavie Miller (age 71) > > 67 Shoreham Avenue > > Ottawa, Canada, K2G 3X3 > > dxd AUG/99 > > INF OCT/99 to FEB/00, CHF > > No meds FEB/00 to JAN/01 > > Gleevec since MAR/27/01 (400 mg) > > CCR SEP/01. #102 in Zero Club > > 2.8 log reduction Sep/05 > > 3.0 log reduction Jan/06 > > 2.9 log reduction Feb/07 > > 3.6 log reduction Apr/08 > > 3.6 log reduction Sep/08 > > 3.7 log reduction Jan/09 > > 3.8 log reduction May/09 > > 3.8 log reduction Aug/09 > > e-mail: [email protected] > > Tel: 613-726-1117 > > Fax: 613-482-4801 > > Cell: 613-282-0204 > > Yahoo ID: zaviem > > > > > > > -- Zavie Miller (age 71) 67 Shoreham Avenue Ottawa, Canada, K2G 3X3 dxd AUG/99 INF OCT/99 to FEB/00, CHF No meds FEB/00 to JAN/01 Gleevec since MAR/27/01 (400 mg) CCR SEP/01. #102 in Zero Club 2.8 log reduction Sep/05 3.0 log reduction Jan/06 2.9 log reduction Feb/07 3.6 log reduction Apr/08 3.6 log reduction Sep/08 3.7 log reduction Jan/09 3.8 log reduction May/09 3.8 log reduction Aug/09 e-mail: [email protected] Tel: 613-726-1117 Fax: 613-482-4801 Cell: 613-282-0204 Yahoo ID: zaviem --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
