Hey Zavie, I just wanted to say hello to you and Ida. I am #1 on your list
Be sure to let Ida know I said hello. Marty Gartenberg On Tue, Nov 3, 2009 at 5:09 PM, Zavie Miller <[email protected]> wrote: > Hi Dawn, > > Log reduction is just a mathematical term. It means 10 times greater or ten > times less. > > So, we use the term log reduction most of the time when we are talking > about CML. If you have a 1 log reduction with your CML it means that there > are 10 times less CML cells in your system since the last time you measured > it. If it is a 2 log reduction, it means that there are 100 times less CML > cells. And a 3 log reduction means 1,000 times less CML cells. > > In order for this to be meaningful you need to know how many CML cells you > started with at diagnosis time. Since very few of us had a PCR test done at > diagnosis time, each lab makes a guess at what the CML level was at > diagnosis time for CML patients at that lab. You don't have to know what > that number is because all the labs report your results in log reduction. > > If you look at my results you will see that I am at a 3.8 log reduction. > This means that the CML level in my system is 1,800 times less than it was > at diagnosis time. A very good place to be. > > Many times you will read that someone is at PCRU. This means that the lab > performing the PCR test could not find any CML cells in your system. Well, > it turns out that some labs do very sensitive PCRs and others do less > sensitive PCRs. So, if you took two samples of your blood to two different > labs one result could come back as a 3.8 log reduction and the other could > come back as PCRU or undetectable. All this means is that the second lab had > a less sensitive test than the first one. > > In order to be able to see how you are doing, you need to be tested at the > same lab under the same conditions in order to compare results. > > I realize that this was a long winded answer and I hope it helped to > unravel the mystery of log reduction. > > A couple of numbers to be aware of. If your resut is a 2 log reduction it > means that you are in CCR (Complete Cytogenic Response). If your result is a > 3 log reduction it means that you are in MMR (Major Molecular Response). > Once you reach MMR there is virtually no chance that you will relapse with > your CML. > > I assign Zero Club numbers when a patient achieves CCR. > > Zavie > > Zavie Miller (age 71) > > 67 Shoreham Avenue > > Ottawa, Canada, K2G 3X3 > > dxd AUG/99 > > INF OCT/99 to FEB/00, CHF > > No meds FEB/00 to JAN/01 > > Gleevec since MAR/27/01 (400 mg) > > CCR SEP/01. #102 in Zero Club > > 2.8 log reduction Sep/05 > > 3.0 log reduction Jan/06 > > 2.9 log reduction Feb/07 > > 3.6 log reduction Apr/08 > > 3.6 log reduction Sep/08 > > 3.7 log reduction Jan/09 > > 3.8 log reduction May/09 > > 3.8 log reduction Aug/09 > > e-mail: [email protected] > > Tel: 613-726-1117 > > Fax: 613-482-4801 > > Cell: 613-282-0204 > > Yahoo ID: zaviem > > > On Wed, Oct 21, 2009 at 10:39 AM, DAWN RODEGHIER <[email protected] > > wrote: > >> Zavie, I don't know what LOG REDUCTION is or how it effects our >> Leukemia! Could you explain it! I'm probably not the only one that needs >> this knowledge. Jim Rodeghier >> >> --- On *Tue, 10/20/09, Zavie Miller <[email protected]>* wrote: >> >> >> From: Zavie Miller <[email protected]> >> Subject: [CMLHope] Novartis drug TasignaR meets primary endpoint in >> pivotal trial against GlivecR as first-line treatment in chronic myeloid >> leukemia patients >> To: [email protected], [email protected] >> Date: Tuesday, October 20, 2009, 11:40 PM >> >> >> >> >> * >> http://www.pipelinereview.com/index.php/2009102030206/Small-Molecules/Novartis-drug-Tasigna-meets-primary-endpoint-in-pivotal-trial-against-Glivec-as-first-line-treatment-in-chronic-myeloid-leukemia-patients.html >> *** >> >> >> >> >> >> >> >> Zavie Miller (age 71) >> >> 67 Shoreham Avenue >> >> Ottawa, Canada, K2G 3X3 >> >> dxd AUG/99 >> >> INF OCT/99 to FEB/00, CHF >> >> No meds FEB/00 to JAN/01 >> >> Gleevec since MAR/27/01 (400 mg) >> >> CCR SEP/01. #102 in Zero Club >> >> 2.8 log reduction Sep/05 >> >> 3.0 log reduction Jan/06 >> >> 2.9 log reduction Feb/07 >> >> 3.6 log reduction Apr/08 >> >> 3.6 log reduction Sep/08 >> >> 3.7 log reduction Jan/09 >> >> 3.8 log reduction May/09 >> >> 3.8 log reduction Aug/09 >> >> e-mail: [email protected] >> >> Tel: 613-726-1117 >> >> Fax: 613-482-4801 >> >> Cell: 613-282-0204 >> >> Yahoo ID: zaviem >> >> >> >> >> >> > > > -- > Zavie Miller (age 71) > 67 Shoreham Avenue > Ottawa, Canada, K2G 3X3 > dxd AUG/99 > INF OCT/99 to FEB/00, CHF > No meds FEB/00 to JAN/01 > Gleevec since MAR/27/01 (400 mg) > CCR SEP/01. #102 in Zero Club > 2.8 log reduction Sep/05 > 3.0 log reduction Jan/06 > 2.9 log reduction Feb/07 > 3.6 log reduction Apr/08 > 3.6 log reduction Sep/08 > 3.7 log reduction Jan/09 > 3.8 log reduction May/09 > 3.8 log reduction Aug/09 > e-mail: [email protected] > Tel: 613-726-1117 > Fax: 613-482-4801 > Cell: 613-282-0204 > Yahoo ID: zaviem > > > > > --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. 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