Karyn, Email Dr. Talpaz with your questions: [email protected] Please include these words in your subject line “CML Combo Trials”.
Christine On Mar 18, 3:48 pm, [email protected] wrote: > Hi Jerry, > > This is very exciting news - thank you for posting it for us!! I do have one > question about the trial - would it require bmbs or aspirations? I would like > to know exactly what they would require at each 3 month visit, if possible. > Thanks so much for your info. > > Karyn > > ----- Original Message ----- > From: "Zavie Miller" <[email protected]> > To: "cmlh...@googlegroups. com" <[email protected]> > Sent: Thursday, March 18, 2010 11:26:07 AM GMT -07:00 U.S. Mountain Time > (Arizona) > Subject: [CMLHope] CML Combo/Trials...The cure we have been waiting for? > > Jerry Posted this on his CMLNEWDRUG.COM website. > > CML Combo/Trials...The cure we have been waiting for? > > by Jerry Mayfield > > Yesterday (March 17, 2010), I met with Dr. Talpaz about his Combo trials. The > purpose of this post is to share information about these trials with you all. > > First, I want to share with those who are new to CML, a little background > about Dr. Talpaz. Over the last 30 plus years, first at M. D. Anderson and > now at the University of Michigan Medical Center, Dr. Moshe Talpaz has been > doing research and treating thousands of CML patients. During that time, he > has become world renowned as a researcher and pioneer in the treatment of > CML. He was the first to prove that Interferon could be used effectively in > the treatment of CML. He was one of the original three doctors to first use > Gleevec in the treatment of CML. He was one of the first two doctors to use > Sprycel to treat CML. He regularly travels the world to lecture about the > latest research and treatment for CML. Some call him "The Guru of CML". He is > certainly a superstar in the world of CML research and treatment. > > I have known Dr. Talpaz for 11 years now and I have never seen him more > excited about the prospect of finding a cure for CML. For the last several > years he has talked to me about the prospect of combining the proven immune > stimulation of Interferon with the effective targeted killing of CML cells by > the new tyrosine kinase inhibitors (TKIs) and how these combos might bring a > cure for many CML patients. He is now conducting a Gleevec/Interferon trial > and plans a Sprycel/Interferon trial to start in the next three months. He > has further plans to combine Interferon with Tasigna and also Bosutinib if it > gains FDA approval. Another possible pathway to a cure that he wants to trial > is combining TKIs with Hedgehog Pathway Inhibitors. Some of these Hedgehog > Pathway Inhibitors target the primitive stem cells that cause CML. These > primitive stem cells are not eliminated by the current drugs used alone. All > this is very exciting stuff. For as long as I have known Dr. Talpaz, he has > always had an uncanny ability to look at the preclinical data about a drug > and predict whether it will be a major player in the CML world. This ability > has put him at the forefront of CML research. I have never seen him more > excited about a prospective trial. He is literally bubbling over with > optimism that this strategy will bring us the cure that we have been waiting > for. We should all be very hopeful for the future. > > Here are answers to some questions about Dr. Talpaz’s Combo Trials: > > 1. How do these trials work? Patients take the drug combination for two years > then stop all CML drugs and are monitored by PCR to see it they remain CML > free. > > 2. Do I have to be PCRU? No you do not have to be PCRU. A three log reduction > defined by Dr. Talpaz as a PCR result if 0.100% or below is required to > participate. > > 3. How much of my time will it take? After the first visit, another in 3 > months and after that every 6 months or yearly. > > 4. Will I have bad side effects form the interferon? No, the dose of > pegylated Interferon used in the trial are miniscule, just a small fraction > of a normal dose. Most patients do not have any significant side effects. > > 5. Are there any other trial centers? No, these trials are located at the > University of Michigan in Ann Arbor Michigan. There may be other doctors > around the world doing similar trials but I do not have the information about > them. > > 6. How do I get more information? Doctor Talpaz requests that you contact him > directly by email at [email protected] Please include these words in your > subject line "CML Combo Trials". > > All this is very exciting but it can’t happen without your help. Patients > must be recruited then remain on the trial for two years before stopping the > drugs. Then they must be followed for several years in order to obtain the > data needed. This is a long process and for the trials to be valid, there > must be a substantial number of participants. Dr. Talpaz says that so far > recruitment has been slow. He has devoted his life to CML. His dream is to > find the cure. This is our chance to help him and at the same time to help > ourselves and the CML community world wide. Please consider doing your part. > > Regards, > > Jerry > > Zavie > - > Zavie Miller (age 71) > 67 Shoreham Avenue > Ottawa, Canada, K2G 3X3 > dxd AUG/99 > INF OCT/99 to FEB/00, CHF > No meds FEB/00 to JAN/01 > Gleevec since MAR/27/01 (400 mg) > CCR SEP/01. #102 in Zero Club > 2.8 log reduction Sep/05 > 3.0 log reduction Jan/06 > 2.9 log reduction Feb/07 > 3.6 log reduction Apr/08 > 3.6 log reduction Sep/08 > 3.7 log reduction Jan/09 > 3.8 log reduction May/09 > 3.8 log reduction Aug/09 > e-mail: [email protected] > Tel: 613-726-1117 > Fax: 613-482-4801 > Cell: 613-282-0204 > Yahoo ID: zaviem > > -- > [CMLHope] > A support group ofhttp://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group athttp://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. 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