There is a similar clinical trial going on in Johns Hopkins with Dr. Doug Smith. I am reviewing the paperwork now with my local onc- and am seriously considering this one because it is closer for me (I am in the Washington DC area-- Hopkins is in Baltimore).
On Mar 29, 10:37 pm, "Tony Lanoue" <[email protected]> wrote: > I'm seriously thinking of joining this clinical trial is anyone else. Any > thoughts? > > _____ > > From: [email protected] [mailto:[email protected]] On Behalf > Of Zavie Miller > Sent: March-18-10 2:26 PM > To: cmlh...@googlegroups. com > Subject: [Possible Spam][CMLHope] CML Combo/Trials...The cure we have been > waiting for? > > Jerry Posted this on his CMLNEWDRUG.COM website. > > CML Combo/Trials...The cure we have been waiting for? > > by Jerry Mayfield > > Yesterday (March 17, 2010), I met with Dr. Talpaz about his Combo trials. > The purpose of this post is to share information about these trials with you > all. > > First, I want to share with those who are new to CML, a little background > about Dr. Talpaz. Over the last 30 plus years, first at M. D. Anderson and > now at the University of Michigan Medical Center, Dr. Moshe Talpaz has been > doing research and treating thousands of CML patients. During that time, he > has become world renowned as a researcher and pioneer in the treatment of > CML. He was the first to prove that Interferon could be used effectively in > the treatment of CML. He was one of the original three doctors to first use > Gleevec in the treatment of CML. He was one of the first two doctors to use > Sprycel to treat CML. He regularly travels the world to lecture about the > latest research and treatment for CML. Some call him "The Guru of CML". He > is certainly a superstar in the world of CML research and treatment. > > I have known Dr. Talpaz for 11 years now and I have never seen him more > excited about the prospect of finding a cure for CML. For the last several > years he has talked to me about the prospect of combining the proven immune > stimulation of Interferon with the effective targeted killing of CML cells > by the new tyrosine kinase inhibitors (TKIs) and how these combos might > bring a cure for many CML patients. He is now conducting a > Gleevec/Interferon trial and plans a Sprycel/Interferon trial to start in > the next three months. He has further plans to combine Interferon with > Tasigna and also Bosutinib if it gains FDA approval. Another possible > pathway to a cure that he wants to trial is combining TKIs with Hedgehog > Pathway Inhibitors. Some of these Hedgehog Pathway Inhibitors target the > primitive stem cells that cause CML. These primitive stem cells are not > eliminated by the current drugs used alone. All this is very exciting stuff. > For as long as I have known Dr. Talpaz, he has always had an uncanny ability > to look at the preclinical data about a drug and predict whether it will be > a major player in the CML world. This ability has put him at the forefront > of CML research. I have never seen him more excited about a prospective > trial. He is literally bubbling over with optimism that this strategy will > bring us the cure that we have been waiting for. We should all be very > hopeful for the future. > > Here are answers to some questions about Dr. Talpaz's Combo Trials: > > 1. How do these trials work? Patients take the drug combination for two > years then stop all CML drugs and are monitored by PCR to see it they remain > CML free. > > 2. Do I have to be PCRU? No you do not have to be PCRU. A three log > reduction defined by Dr. Talpaz as a PCR result if 0.100% or below is > required to participate. > > 3. How much of my time will it take? After the first visit, another in 3 > months and after that every 6 months or yearly. > > 4. Will I have bad side effects form the interferon? No, the dose of > pegylated Interferon used in the trial are miniscule, just a small fraction > of a normal dose. Most patients do not have any significant side effects. > > 5. Are there any other trial centers? No, these trials are located at the > University of Michigan in Ann Arbor Michigan. There may be other doctors > around the world doing similar trials but I do not have the information > about them. > > 6. How do I get more information? Doctor Talpaz requests that you contact > him directly by email at [email protected] Please include these words in > your subject line "CML Combo Trials". > > All this is very exciting but it can't happen without your help. Patients > must be recruited then remain on the trial for two years before stopping the > drugs. Then they must be followed for several years in order to obtain the > data needed. This is a long process and for the trials to be valid, there > must be a substantial number of participants. Dr. Talpaz says that so far > recruitment has been slow. He has devoted his life to CML. His dream is to > find the cure. This is our chance to help him and at the same time to help > ourselves and the CML community world wide. Please consider doing your part. > > Regards, > > Jerry > > Zavie > - > Zavie Miller (age 71) > 67 Shoreham Avenue > Ottawa, Canada, K2G 3X3 > dxd AUG/99 > INF OCT/99 to FEB/00, CHF > No meds FEB/00 to JAN/01 > Gleevec since MAR/27/01 (400 mg) > CCR SEP/01. #102 in Zero Club > 2.8 log reduction Sep/05 > 3.0 log reduction Jan/06 > 2.9 log reduction Feb/07 > 3.6 log reduction Apr/08 > 3.6 log reduction Sep/08 > 3.7 log reduction Jan/09 > 3.8 log reduction May/09 > 3.8 log reduction Aug/09 > e-mail: [email protected] > Tel: 613-726-1117 > Fax: 613-482-4801 > Cell: 613-282-0204 > Yahoo ID: zaviem > > -- > [CMLHope] > A support group ofhttp://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group athttp://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. 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