Hi everybody :) After reading your posts for a few months, I thought it is time that I introduce myself. My name is Peter (62), I am from Whitby, Ontario. I was diagnosed with CML in May 2010. It took me about a year to get used to Gleevec, to the point where I could (kindof) live with it. At the end of two years, the only remaining issues were chills, muscle cramps and some fluid retention. The problem was, it did not get me any higher than a 2.7 log reduction - close, but no cigar. I switched to 800mg Tasigna, which got me up to 3.4 log within three months. But I could not tolerate the high dosage, so we lowered it to 600mg. Now I am stuck at a 3.0 log reduction, but Tasigna appears to be doing a number on my cardio - hypertension, palpitations, fast pulse, irregular heartbeat. I take Proprapnolol, Cilazapril, Hydro and the occasional Ativan to keep a lid on these issues, but with limited success. In addition, I am also experiencing extreme fatigue and weakness. Has anybody here had these kinds of problems with Tasigna? If yes, I would be really grateful for any helpful hints you can give me.
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