You go, Peg!!! What a great explanation! And I am so anxious to see what my results will be next month, as I have been taking 70 mg of Sprycel, with the Bragg's Vinegar for the past 3 months.My last two PCR's were negative. I swear if it is negative again you will feel me jumping for joy!!!!
Here are the links from the previous posts: The Ever Increasing BCR-ABL Synopsis <http://www.leukemiasurvivor.co/2013/08/the-ever-increasing-bcr-abl-synopsis.html> Absorption; Could This be the Cause<http://www.leukemiasurvivor.co/2013/08/absorption-of-medication-could-this-be.html> Sucking Down the Mother's<http://www.leukemiasurvivor.co/2013/08/sucking-down-mothers.html> A Negative PCR, Really?<http://www.leukemiasurvivor.co/2013/08/a-negative-pcr-really.html> Feel free to share with others! Blessings, Michele On Fri, Mar 14, 2014 at 8:29 AM, peg <[email protected]> wrote: > Hi Beth, > > Hi Beth, > > You are right that increasing absorption of a TKI does render a higher > dose, and for me, yes this caused more side effects on Sprycel, but my side > effects in hindsight were an auto-immune reaction. Here is the thing about > lemon juice, vinegar, coke or anything that increases stomach acid, it is > possible, as gleened from personal annecdotes and my personal experience, > that Sprycel, and possibly other TKI's, actually cause a reduction in > stomach acid over time reducing the amount of absorption of a dose that > would otherwise be affective on our CML. There are still so many unknowns > about these drugs. Whether that is the case or not, at a point where a > dose is no longer affective, doctors have simply increased the dose, rather > than trying to increase the absorption! I personally think that there is > more control over how much you are absorbing and the toxicity of a drug by > simply restoring your ability to absorb a medication rather than increasing > the dose. If you are taking, let's say, 100mg of a drug daily, increasing > the absorbtion by intentionally increasing acidity still can never give you > more than 100mg, but if you increase that dose to 140mg, on any given day > you could absorb more...up to the full 140mg, as the acidity level is > natually affected in your stomach by what you eat. Sort of like why a > particular food will give you heartburn on one day but not another...due to > natural fluctuations in stomach acid. This is just my thought on this. > > As an interesting side note, when this vinegar topic came up here last > year, I had noticed that not only was my sprycel dose not as affective but > that every time I ate I got stomach pain and indigestion. On an > experiment, I tried lemon juice to ease the indigestion and stomach pain > and it worked. There is much anecdotal evidence of this online as an > indigestion aide. So to take my experiment one step further, I started > swigging lemon juice before my meals, and it completely put an end to my > indigestion! > > As far as wound healing...yes...this was my experience also on all of the > TKI drugs, wounds do not heal well or quickly! In the case of Sprycel, my > skin was extremely dry and did not heal well from any type of wound, > surgical or injury. I also noticed that I had an absorbtion problem from > medication patches...in my case estrogen...it simply did not absorb well. > I also had a more extreme reaction to chlorine when I was doing pool > therapy, but found that using a heavy mosturizer prior to contact kept me > from breaking out in an itchy rash. Wounds will eventually heal but must > be safeguarded, with extreme vigilence, from infection due to the slower > healing time. Hang in there! > > Hope my thoughts are able to help in some way. > > Peg > > > -- > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at > http://groups.google.com/group/CMLHope > --- > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To unsubscribe from this group and stop receiving emails from it, send an > email to [email protected]. > For more options, visit https://groups.google.com/d/optout. > -- [email protected] www.LearntoBallroomDanceOnline.com -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.
