The computational biology of aging and circadian rhythms, and implications for human health is coming at 10/21/2019 - 4:00pm
Gilfillan Auditorium Mon, 10/21/2019 - 4:00pm David Hendrix Associate Professor, Department of Biochemistry and Biophysics, and, School of Electrical Engineering and Computer Science Abstract: The circadian system is a regulatory network hub that temporally coordinates molecular, cellular and physiological processes. Circadian coordination of neural functions contributes to healthy aging, and the expression of hundreds of genes change in a daily pattern due to circadian regulation. To understand age-related changes in rhythmically expressed genes, we performed around-the-clock RNA-seq and small RNA-seq in the heads of 5-day-old (young) and 55-day-old (old) flies. In this study, we present an analysis of obtained data. Our methods build upon Fourier-based detection of changes in rhythmic expression, and can also detect rhythmic bursts of expression that are not detected with other Fourier-based approaches. Although the net level of rhythmicity remains constant after aging, we observe a "rewiring" of the circadian system. First, we observe changes in the core clock genes, such as the expression of /period/, which exhibits an increase in the amplitude of mRNA expression and a reduction in protein expression. We observe several stress-response genes, late life cyclers (LLCs), that gain rhythmicity during aging. We also present some preliminary data on oscillatory expression of genes in humans. The computational analysis and data we present will shed new light on the widespread shifts in gene regulation and metabolic pathways to cope with the changing cellular environment during aging. This talk will also provide the much of the biological background needed to understand the analysis. Bio: Read more: https://eecs.oregonstate.edu/colloquium/computational-biology-aging-and-... [1] [1] https://eecs.oregonstate.edu/colloquium/computational-biology-aging-and-circadian-rhythms-and-implications-human-health
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