I seem to be having the same problem as mentioned in this message:
http://lists.gispython.org/pipermail/community/2009-August/002162.html

I download svn version 1466, spatiallibrary as per website, and build
works fine. In python prompt, though, I get
 File "<stdin>", line 1, in <module>
 File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/Rtree-0.5.0-py2.6.egg/rtree/__init__.py",
line 8, in <module>
   from index import Rtree
 File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/Rtree-0.5.0-py2.6.egg/rtree/index.py",
line 2, in <module>
   import core
 File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/site-packages/Rtree-0.5.0-py2.6.egg/rtree/core.py",
line 88, in <module>
   rt = ctypes.CDLL(lib_name)
 File 
"/Library/Frameworks/Python.framework/Versions/2.6/lib/python2.6/ctypes/__init__.py",
line 353, in __init__
   self._handle = _dlopen(self._name, mode)
OSError: dlopen(libspatialindex_c.dylib, 6): image not found

which is the same error. Setting LD_LIBRARY_PATH to the location of
the Rtree egg directory doesn't work, however.

Any ideas? I wonder if the dylib is not being found (I'm not clear on
the equivalent to ldconfig for the Mac).

Here is my local library path:
Rtree $ ls -la /usr/local/lib/libspatialindex.*
-rwxr-xr-x  1 root  wheel   964192 19 Oct 16:32
/usr/local/lib/libspatialindex.1.dylib
-rw-r--r--  1 root  wheel  1551344 19 Oct 16:32 /usr/local/lib/libspatialindex.a
lrwxr-xr-x  1 root  wheel       23 19 Oct 16:32
/usr/local/lib/libspatialindex.dylib -> libspatialindex.1.dylib
-rwxr-xr-x  1 root  wheel      992 19 Oct 16:32
/usr/local/lib/libspatialindex.la
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