On 09/02/2021 16:04, Ming Sun wrote:

Thanks for the information. I did give another several try. However, I got the 
same error messages.
using the GUI, mutating A --> T; not working; (but could do it from A to U)

For me, it was the other way around.

using the python script, mutate nucleotide or mutate residue functions, it 
would work for U but not T
loading a PDB (DNA protein complexes), T denoted as DT in the pdb file, 
mutating A to T using the script; again, it would for U but not T

Hmmm... so confusing. I think there may be a bug.

Re the coot, the latest macOS stand-alone version of COOT I found is 0.8.9.3 
pre-EL. Any other place I should look to download a more updated version?


This is a sad state of affairs. Making stand-alone binaries for Mac is a painstaking (and invisible) undertaking. There is no good solution at the moment.

A pretty recent Coot is bundled with CCP4 and a more recent one still can be 
found in CCPEM nightly binaries.

Paul.

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