-Caveat Lector-
------- Forwarded message follows -------
Date sent: Sat, 23 Jun 2001 22:46:28 -0700
From: Anise Mann <[EMAIL PROTECTED]>
Subject: Re: [MC] Effexorwith Haloperidol and/or Risperidone
To: [EMAIL PROTECTED]
Send reply to: [EMAIL PROTECTED]
Effexor, when used with Haloperidol and/or Risperidone, increases the AUC
(Area Under the Curve, or "full drug exposure ") level of both drugs
significantly:
http://www.effexorxr.com/pi.htm#contraindications
Haloperidol
Venlafaxine administered under steady-state conditions at 150 mg/day in 24
healthy subjects decreased total oral-dose clearance (Cl/F) of a single 2 mg
dose of haloperidol by 42%, which resulted in a 70% increase in haloperidol
AUC. In addition, the haloperidol Cmax increased 88% when coadministered
with venlafaxine, but the haloperidol elimination half-life (t&189;) was
unchanged. The mechanism explaining this finding is unknown.
--
Risperidone - Venlafaxine administered under steady-state conditions at 150
mg/day slightly inhibited the CYP2D6-mediated metabolism of risperidone
(administered as a single 1 mg oral dose) to its active metabolite,
9-hydroxyrisperidone, resulting in an approximate 32% increase in
risperidone AUC. However, venlafaxine coadministration did not significantly
alter the pharmacokinetic profile of the total active moiety (risperidone
plus 9-hydroxyrisperidone.)
-----
Doctors are hazardous to your health, IMO.
Anise
>Wellbutrin, Remeron and Effexor are anti-depressants that affect
>neurotransmitters. Remeron, one of the newer anti-depressants, stimulates
>serotonin release while blocking specific serotonin receptors. All three
>are
>commonly prescribed for depression.
>
>Haldol, an anti-psychotic manufactured by Ortho-McNeil, is often prescribed
>for schizophrenia and outbursts of aggression and agitation. It also works
>by
>changing the flow of dopamine.
>
------- End of forwarded message -------
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