-Caveat Lector-

February 3, 2003
http://www.nytimes.com/2003/02/03/health/03BLOO.html
Quarantine Expands as White Substance Is Found in More Blood

By MICHAEL WILSON

Blood in the Nashville region was quarantined yesterday after a mysterious
white fatty substance was found in three samples of donated blood, the
Red Cross said. The discovery came two days after 110 units containing the
substance were found in Atlanta.

No harmful effects on patients have been reported.

The substance has not been identified. It is described as floating in sealed
blood bags either invisibly in tiny particles or in pea-size globs.

"It doesn't appear to be human in origin," said Dr. Christopher D. Hillyer, an
Emory University professor who works with the Red Cross. There have
been no reports of patients receiving the tainted blood, and officials said
they had no idea what would happen if they did.

The Nashville quarantine affects hospitals in parts of Kentucky and Illinois
as well as Tennessee, shelving about 70 percent of the region's Red Cross
blood supply, said Ryland Dodge, a spokesman. Hospitals were being
notified last night.

On Friday, the Red Cross quarantined thousands of units of blood after the
110 units in Atlanta, out of about 4,000 tested, were found to contain the
substance.

In all the cases, the blood was in plastic bags manufactured by the Baxter
Healthcare Corporation, a subsidiary of Baxter International Inc. A
spokesman for the company could not be reached yesterday. On Friday, a
spokeswoman for Baxter Healthcare, based in Deerfield, Ill., said the
company had done its own preliminary tests on four samples and found
nothing wrong with the bags.

The Red Cross is replacing the quarantined blood with blood from
elsewhere in the country, Mr. Dodge said. Likewise, 2,000 units were
shipped to Atlanta after Friday's discovery.

"I don't think anybody knows right now" what the substance is or whether
it will appear in another region, said Karen Shoos Lipton of the American
Association of Blood Banks. "I think the thing we take some comfort in is
we haven't had any reports of patient-adverse reactions."

The Food and Drug Administration is investigating, along with state
authorities, the Red Cross, Baxter and the Centers for Disease Control and
Prevention.

"The F.D.A. is aware the scope has expanded outside of the Atlanta area,
and that is part of our investigation," said Jason Brodsky, a spokesman for
the agency.

The centers tested the samples for a variety of bacterial and bio-threat
agents, and the results were negative, said Dr. Peter Page of the Red
Cross. Further chemical tests are continuing.


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