Thanks a lot for the long and accurate answer!
I agree that the problem probably is in some strange interaction between
versions ... in a system that is the result of years of
upgrade+dist-upgrade.
The solution could be taking one day to rebuild it from scratch ... hoping
one day is enough! :-)
Let's try a last time.

May be at a glance you see something strange!?

Giorgio
(my answers below)


I currently tend to think there is something fishy within your system,
> maybe something miss configured or package version mixed up, you've
> written about some external included sources.
>

Thanks for the kind and complete answer!

I currently tend to think there is something fishy within your system,
> maybe something miss configured or package version mixed up, you've
> written about some external included sources.
>

The external packages are only few, I exclude this could be the problem.
They are:
  - epoptes-client: 22.01-1+202208211647~ubuntu20.04.1 from
http://ppa.launchpad.net/ltsp/ppa/ubuntu focal/main amd64 Packages
  - google-drive-ocamlfuse: 0.7.27-0ubuntu1~ubuntu16.04.1 from
http://ppa.launchpad.net/alessandro-strada/ppa/ubuntu xenial/main amd64
Packages
  - google-chrome-stable: 105.0.5195.52-1 from
http://dl.google.com/linux/chrome/deb stable/main amd64 Packages

It's quite impossible to debug anything from a remote side as your local
> system is like a black box for others as there is nothing really known
> except the information you are using XFCE on a sid system. There is no
> knowledge about used versions of the various packages.
>

 I've installed reportbug and sent info from there ... they will appear in
this tread (I hope).


Some side note about the pre-compiled upstream TB versions, they come
> with all required libraries included, so it's not really something
> special that these versions are "really" working.


This excludes a BUG in TB itself.
 NOTE: also pre-compiled fails when I run it in my "testing" station.

The menu Help provides some entries which can be used to get more
> information about the current profile and processes and used modules.
> Compare the output.
>
> In most cases the JS console helps to find out what missing or not fully
> working.
>

I' paste from the JS console ...

This page is in Quirks Mode. Page layout may be impacted. For Standards
Mode use “<!DOCTYPE html>”.
hiddenWindow.html
This page is in Quirks Mode. Page layout may be impacted. For Standards
Mode use “<!DOCTYPE html>”.
AddonRepository.jsm:97:12
Trying to load /usr/lib/thunderbird/libotr.so OTRLib.jsm:64:11
Trying to load libotr.so from system's standard library locations OTRLib.jsm
:64:11
Trying to load libotr.so.5 from system's standard library locations
OTRLib.jsm:64:11
Trying to load libotr.so from system's standard library locations OTRLib.jsm
:64:11
Error: Cannot load required OTR library
    loadExternalOTRLib resource:///modules/OTRLib.jsm:109
    init resource:///modules/OTRLib.jsm:115
    once resource:///modules/OTR.jsm:117
    init resource:///modules/OTR.jsm:138
    init resource:///modules/OTRUI.jsm:255
OTR.jsm:126:15
Successfully loaded OpenPGP library librnp.so.0 version 0.16.0-1 from
system's standard library locations RNPLib.jsm:100:15
RangeError: invalid language tag: "it-IT-euro" mozIntl.jsm:866:24
Uncaught (in promise)
Exception { name: "NS_ERROR_XPC_JAVASCRIPT_ERROR_WITH_DETAILS",
message: "[JavaScript
Error: \"invalid language tag: \"it-IT-euro\"\" {file:
\"resource://gre/modules/mozIntl.jsm\" line: 866}]'[JavaScript Error:
\"invalid language tag: \"it-IT-euro\"\" {file:
\"resource://gre/modules/mozIntl.jsm\" line: 866}]' when calling method:
[mozIMozIntl::getCalendarInfo]", result: 2153185313, filename:
"resource:///modules/calendar/utils/calL10NUtils.jsm", lineNumber: 66,
columnNumber: 0, data: XPCWrappedNative_NoHelper, stack: "_calendarInfo
@resource:///modules/calendar/utils/calL10NUtils.jsm:66:30\
nsetLocaleDefaultPreferences
@chrome://calendar/content/calendar-chrome-startup.js:318:31\
nloadCalendarComponent
@chrome://calendar/content/calendar-chrome-startup.js:50:3\n", location:
XPCWrappedNative_NoHelper }
calL10NUtils.jsm:66
Found 0 public keys and 0 secret keys (0 protected, 0 unprotected)
RNPLib.jsm:301:15
services.settings: Failed to load last_modified.json: TypeError:
NetworkError when attempting to fetch resource.

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