Another option is to use a desktop publishing program such as Ventura Publisher or Pagemaker. Both of these programs are professional level commercial programs and quite expensive. Of the two, I prefer Ventura Publisher. There are also some free programs such as Scribus. I have never used Scribus, but I see it recommended all of the time.
I have used LaTeX to design 9 text books successfully with Lulu.com as well as 2 picture books with Scribus and they worked great. I even did a reference book just with HTMLdoc. Pagemaker is no longer in development - you now have to go with Adobe In Design or QuarkExpress which are much more complicated. Another route is to try Multi Ad Creator Desktop - I knew my University used it for their daily newspaper. Do NOT use Apple Pages if you want to use Lulu.com because the fonts are not embedded right and it will automatically be rejected.
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