Hi. I have a sample of M tumors from a set of N patients. For each tumor I measured a continuos variable pre and post treatment.
If M=N (and assuming conditions for t-test applicability being satisfied) then a paired t-test is one of the right tests for evaluating treatment efficacy (and Wilcoxon sign rank test, too). If M > N then the non independence between tumors must be taken into account. In fact, some patients have more than one tumor. Therefore I need some kind of corrected paired test which considers the effect of this non independence in the observations. Unfortunately I am not aware if this test exists. Please, could you give me an idea on how to solve this problem ? Thanks in advance, Marco (from Verona - Italy) . . ================================================================= Instructions for joining and leaving this list, remarks about the problem of INAPPROPRIATE MESSAGES, and archives are available at: . http://jse.stat.ncsu.edu/ . =================================================================
