I'm glad to use Python3, but FYI regarding the discussion in 
https://github.com/emscripten-core/emsdk/pull/561: on my Mac running 10.14, 
I do need root to change /usr/local:

% ls -ld /usr/local
drwxr-xr-x  14 root  wheel  448 Jun 10 07:14 /usr/local

% ls -ld /usr/local/*
drwxr-xr-x  105 root  wheel  3360 Jun 12 10:32 /usr/local/bin
drwxr-xr-x    7 root  wheel   224 Oct 30  2018 /usr/local/gfortran
drwxr-xr-x   12 root  wheel   384 Jun  4 15:49 /usr/local/include
drwxr-xr-x    5 root  wheel   160 Feb 21  2019 /usr/local/info
drwxr-xr-x   49 root  wheel  1568 Jun  4 15:49 /usr/local/lib
drwxr-xr-x    2 root  wheel    64 Jun  9  2019 /usr/local/libexec
drwxr-xr-x    3 root  wheel    96 Feb 21  2019 /usr/local/man
drwxr-xr-x    9 root  wheel   288 Jun  4 15:33 /usr/local/share

% mkdir /usr/local/opt
mkdir: /usr/local/opt/: Permission denied

I'm  not using homebrew, so I don't know if there is something special 
about their/your configuration or something obsolete about mine ... but 
over the course of many versions of OSX/macOS, I've never been able to 
write to /usr/local without root ...

Eric

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