Zinc Fingers are a dead technology. They were killed by patents. There was an open effort, the Zinc Finger Consortium, but they were limited to a small subset of ZF modules. They weren't ever that easy to use, either.. designing them was a brute force effort involving phage display and mass-screening for binding efficiency.
The patent troll in question is now the only one using or developing the tech, after successfully destroying the field. TALENs are/were promising too but are still harder to engineer than CRISPR. More promising is the discovery of Cas analogues or homologues not covered by patent yet, though there are probably already some overbroad "gene editing, period" patents out there. On 21 February 2017 21:36:25 GMT+00:00, Urs Gaudenz <[email protected]> wrote: >763 patent families claim CRISPR Cas9 and years of fighting ahead... >what was the name of that other method, Zink-Fingers, let's just use >that :) > >Urs > >On February 21, 2017 8:48:35 PM GMT+01:00, Markus Schmidt ><[email protected]> wrote: >> Why the CRISPR patent verdict isn’t the end of the story >>http://www.nature.com/news/why-the-crispr-patent-verdict-isn-t-the-end-of-th >>e-story-1.21510 >> >> >> >> >> >>Von: Denisa Kera <[email protected]> >>Datum: Dienstag, 21. Februar 2017 um 19:26 >>An: <[email protected]> >>Cc: Biocommons <[email protected]>, europe >><[email protected]>, Markus Schmidt <[email protected]> >>Betreff: Re: [BHL-Europe] Re: CRISPR patent aftermath >> >>Job of the future: Crispr detectives >>https://www.iarpa.gov/index.php/working-with-iarpa/requests-for-information/ >>detection-of-genome-editing >> >> >> >>On Feb 21, 2017 7:46 AM, "Marc Dusseiller" <[email protected]> wrote: >>> we always leave traces... cos we document everything we do :-) >>> >>> how about yeasts? i think the patent covers mamalian and plant >cells, >>not >>> eukariotes in general? or am i wrong? >>> >>> marc >>> >>> On Tue, Feb 21, 2017 at 10:02 PM, alexander murer >><[email protected]> >>> wrote: >>>> >>>> >>>> Wouldn't worry too much. The good part about patents on tools or >>processes >>>> is, that someone first has to prove that you used it. Crispr/CAS9 >>luckily >>>> doesn't leave any traces. Apart from that it's kind of rare that >>someone is >>>> going to sue you for non-commercial patent activities ;) >>>> >>>> Am 20.02.2017 um 12:22 schrieb Markus Schmidt: >>>>> Hi folks >>>>> >>>>> Here is some new intel to keep you in the picture. >>>>> Last week, US patent authorities granted eukaryote CRISPR patents >>to >>>>> MIT/Harvard Broad Institue (prokaryotes are with UC Berkeley) >>>>> >>https://www.technologyreview.com/s/603662/patent-office-hands-win-in-crispr- >>>>> >>battle-to-broad-institute/?goal=0_997ed6f472-6ee82d4db4-153906933&mc_cid=6ee >>>>> 82d4db4&mc_eid=0b98007850 >>>>> then shares of Editas Genetics, the start up that plans to use >the >>patented >>>>> tech for gene therapy, anti-aging etc jumped accordingly >>>>> >>http://www.nasdaq.com/de/symbol/edit/interactive-chart?timeframe=5d&charttyp >>>>> e=line >>>>> And then Georg Church, co founder of Editas proclaimed that with >a >>few >>>>> years CRISPR will be used to REVERSE aging (among others). >>>>> >>http://www.nextbigfuture.com/2017/02/george-church-indicates-reversal-of.htm >>>>> l?m=1 >>>>> >>>>> The situation in Europe is no different, see e.g. >>>>> https://register.epo.org/application?number=EP16742455 >>>>> Among the many patents registered at EPO. >>>>> >>>>> So folks, whatever you CRISPR in your kitchens, for the next 20 >>years or so >>>>> it will be DIY in the strict sense, for YOURSELF, with exceptions >>maybe for >>>>> research or educatiuonal purposes, but not for others as that will >>be patent >>>>> infringements - if you don’t plan to strike a deal. >>>>> >>>>> Cheers. >>>>> >>>>> Markus >>>>> >>>>> >>>>> >>>>> >>>>> >>>>> Von: Pieter van Boheemen <[email protected]> >>>>> Datum: Donnerstag, 9. Februar 2017 um 17:39 >>>>> An: <[email protected]> >>>>> Cc: Markus Schmidt <[email protected]>, europe >>>>> <[email protected]>, Biocommons <[email protected]> >>>>> Betreff: Re: Accessible Bio Companies Back Up DIY Kits >>>>> >>>>> Great page Marc! >>>>> >>>>> Today I am recording a episode for national television on how to >>use the DIY >>>>> crispr kit of The ODIN. It will be on TV some where late May early >>June >>>>> >>>>> http://pers.ntr.nl//programma/van_dna_tot_z/ >>>>> >>>>> Let's see how Dutch regulators respond >>>>> >>>>> waag society || www.waag.org <http://www.waag.org> || sint >>>>> antoniesbreestraat 69 || 1011 hb amsterdam || the netherlands >|| >> +31 >>>>> 614153298 <tel:+31%206%2014153298> || skype pieter.van.boheemen >>>>> >>>>> open wetlab || http://waag.org/en/lab/open-wetlab >>>>> fablab amsterdam || http://fablab.waag.org >>>>> >>>>> ----- Oorspronkelijk bericht ----- >>>>> Van: Marc Dusseiller <[email protected]> >>>>> Aan: Markus Schmidt <[email protected]> >>>>> Cc: europe <[email protected]>, Biocommons >>>>> <[email protected]> >>>>> Verzonden: Thu, 09 Feb 2017 17:25:26 +0100 (CET) >>>>> Onderwerp: Re: Accessible Bio Companies Back Up DIY Kits >>>>> >>>>> i guess we looked into making our kits... just to flush the net >>with funny >>>>> pictures of these dangerous DIYbio stuff :-) >>>>> hackteria.org/wiki/Make_you_own_CRISPR-Kit >>>>> <http://hackteria.org/wiki/Make_you_own_CRISPR-Kit> >>>>> >>>>> m >>>>> >>>>> On Fri, Feb 10, 2017 at 1:21 AM, Markus Schmidt >><[email protected]> >>>>> wrote: >>>>> >>>>>> One more by Gizmodo on the subject: http://gizmodo.com/ >>>>>> germany-is-threatening-biohackers-with-prison-1792143993 >>>>>> >>>>>> >>>>>> Von: Markus Schmidt <[email protected]> >>>>>> Datum: Donnerstag, 9. Februar 2017 um 17:05 >>>>>> An: <[email protected]>, Biocommons >><[email protected]> >>>>>> Betreff: Accessible Bio Companies Back Up DIY Kits >>>>>> >>>>>> Hi folks, >>>>>> >>>>>> Great to see some good response. Here is some more food for >>thought with >>>>>> the potential for lively exchange of views and opinions. >>>>>> >>>>>> You might have seen the Warning by the German government >>institution to be >>>>>> careful when using DIYBio kits. The German „Bundesamt für >>>>>> Verbraucherschutz" has issued a warning for people who think >about >>>>>> purchasing any of the available DIY kits for doing more than >>analytics, say >>>>>> synthetic stuff. In Make Magazine Germany they discuss who would >>be >>>>>> affected and several well known start-ups were mentioned. >>>>>> >>>>>> Warning by Bundesamt für Verbraucherschutz >>>>>> http://www.bvl.bund.de/DE/06_Gentechnik/04_Fachmeldungen/ >>>>>> 2017/2017_01_25_DIY-Kits.html >>>>>> And Make article >>>>>> https://www.heise.de/make/meldung/Biohacking-Bundesamt- >>>>>> warnt-vor-Do-It-Yourself-Kits-3616860.html >>>>>> >>>>>> Today, two of the affected US “Accessible Bio” companies, Amino >>and >>>>>> Biorealize, have issued a statement responding to the warning, >>titled >>>>>> Accessible Bio Companies Back Up the Importance of “Criminal” DIY >>Kits for >>>>>> the Future of Science Education >>>>>> see for yourself: >>>>>> http://www.prweb.com/releases/accessible/bio/prweb14053058.htm >>>>>> >>>>>> Cheers, Markus >>>>>> >>>>> >>>>> >>>>> >>>>> -- >>>>> ******************************************************* >>>>> !!NOTICE: new phone nr: tel: +41 77 9930877 >><tel:+41%2077%20993%2008%2077> >>>>> ******************************************************* >>>>> //////dusjagr labs///////////////////////////////////////// >>>>> Dr. Marc Dusseiller >>>>> Schöneggstr. 34 | CH-8004 Zürich | tel: +41 77 9930877 >>>>> <tel:+41%2077%20993%2008%2077> | skype: dusjagr >>>>> www.dusseiller.ch/labs <http://www.dusseiller.ch/labs> >>>>> ////////////////////////////////////////////////////////////////// >>>>> SGMK | Schweizerische Gesellschaft für Mechatronische Kunst >>>>> Postfach 2161 | CH-8031 Zürich >>>>> www.mechatronicart.ch <http://www.mechatronicart.ch> >>>>> ////////////////////////////////////////////////////////////////// >>>>> hackteria | Open Source Biological Art >>>>> www.hackteria.org <http://www.hackteria.org> >>>>> ////////////////////////////////////////////////////////////////// >>>>> >>>>> >>>> >>> >>> >>> >>> -- >>> ******************************************************* >>> !!NOTICE: new phone nr: tel: +41 77 9930877 >><tel:+41%2077%20993%2008%2077> >>> ******************************************************* >>> //////dusjagr labs///////////////////////////////////////// >>> Dr. Marc Dusseiller >>> Schöneggstr. 34 | CH-8004 Zürich | tel: +41 77 9930877 >>> <tel:+41%2077%20993%2008%2077> | skype: dusjagr >>> www.dusseiller.ch/labs <http://www.dusseiller.ch/labs> >>> ////////////////////////////////////////////////////////////////// >>> SGMK | Schweizerische Gesellschaft für Mechatronische Kunst >>> Postfach 2161 | CH-8031 Zürich >>> www.mechatronicart.ch <http://www.mechatronicart.ch> >>> ////////////////////////////////////////////////////////////////// >>> hackteria | Open Source Biological Art >>> www.hackteria.org <http://www.hackteria.org> >>> ////////////////////////////////////////////////////////////////// > >-- >Sent from my Android device with K-9 Mail. Please excuse my brevity. -- Sent from my Android device with K-9 Mail. Please excuse my brevity.
